Energy-providing bone-repair degradable porous scaffold, preparation method thereof, and application thereof
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United States of America Patent
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Jan 2, 2018
Grant Date -
Aug 31, 2017
app pub date -
Apr 15, 2016
filing date -
Feb 26, 2016
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Abstract
The invention discloses an energy-providing bone-repair degradable porous scaffold, a preparation method thereof, and an application thereof. The invention obtains an energy-based biomaterial solution by compositing gelatin, a polyatomic acid and derivatives thereof, a dibasic alcohol and derivatives thereof, and a tribasic alcohol and derivatives thereof in a chemical cross-linking manner by using diisocyanate, and further obtains a porous scaffold through a drying method. The porous scaffold can avoid the problem of an acidic microenvironment caused by in vivo implantation of the existing biomaterial and keep the activity of an osteoblast cell, thereby improving the rate of repairing the damaged bone tissue with the energy-based biomaterial. The porous scaffold of the invention can be used as a filling material for bone repair in a surgical operation.
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