Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH
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United States of America Patent
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Jan 2, 2018
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app pub date -
Jun 20, 2014
filing date -
Sep 17, 2010
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Abstract
The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration.
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