Methods for multi-resolution analysis of cell-free nucleic acids

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United States of America Patent

PATENT NO 9850523
SERIAL NO

15426668

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The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.

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Patent Owner(s)

Patent OwnerAddress
GUARDANT HEALTH INC505 PENOBSCOT DRIVE REDWOOD CITY CA 94063

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abdueva, Diana Orinda, US 27 231
Chudova, Darya San Jose, US 49 255
Eltoukhy, Helmy Atherton, US 82 1629
Mortimer, Stefanie Ann Ward Morgan Hill, US 67 469

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