Antibodies that recognize IAPP
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United States of America Patent
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Dec 26, 2017
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app pub date -
Jul 11, 2014
filing date -
Jul 12, 2013
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Abstract
The invention provides monoclonal antibody 6B8 and related antibodies. The 6B8 antibody binds to an epitope within residues 3-12 of IAPP. The antibodies of the invention are useful, for example, for treating disorders associated with IAPP accumulation, particularly accumulation of IAPP deposits. Such disorders include type 2 diabetes, metabolic syndrome, impaired insulin tolerance, impaired glucose tolerance, insulinomas, and related conditions.
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