Targeting trastuzumab-resistant HER2+ breast cancer with a HER3-targeting nanoparticle

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United States of America Patent

PATENT NO 9850293
SERIAL NO

14678972

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Abstract

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Disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to treatment with an anti-HER2 therapy; and administering to the patient a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; a nucleic acid molecule bound to the polypeptide sequence via electrostatic interactions; and a chemical agent non-covalently linked to the nucleic acid sequence. Also disclosed are methods of inducing apoptosis in an anti-HER2 therapy resistant HER2+ breast cancer cell, the method comprising contacting the anti-HER2 therapy resistant HER2+ breast cancer cell with the drug delivery molecule. Further disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to anti-HER2 therapy; and administering to the patient a therapeutically effective amount of a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; and a sulfonated corrole molecule bound to the polypeptide sequence. Finally disclosed herein are methods of inducing apoptosis in an anti-HER2 therapy resistant HER2+ breast cancer cell, the method comprising contacting the anti-HER2 therapy resistant HER2+ breast cancer cell with a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; and a sulfonated corrole molecule bound to the polypeptide sequence.

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Patent Owner(s)

Patent OwnerAddress
CEDARS-SINAI MEDICAL CENTER8700 BEVERLY BOULEVARD LOS ANGELES CA 90048

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cui, Xiaojiang Los Angeles, US 15 78
Hanson, Chris Los Angeles, US 14 86
Medina-Kauwe, Lali K Los Angeles, US 16 107
Sims, Jessica Los Angeles, US 3 17
Taguaim, Michael Los Angeles, US 2 17

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