Beta-hairpin peptidomimetics

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United States of America Patent

PATENT NO 9850284
APP PUB NO 20160060298A1
SERIAL NO

14781229

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Beta-hairpin peptidomimetics of the general formula (I), cyclo(P1-p2-p3-p4-p5-p6-p7p8p9-p10-p11-p12-T1-T2], and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have broad spectrum Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

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Patent Owner(s)

Patent OwnerAddress
POLYPHOR AG4123 ALLSCHWIL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bernardini, Francesca Hésingue, FR 11 18
Luther, Anatol Binzen, DE 20 41
Obrecht, Daniel Bättwil, CH 82 589
Zbinden, Peter Magden, CH 11 17

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