Inhibitors of the renal outer medullary potassium channel
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United States of America Patent
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Dec 26, 2017
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Oct 26, 2015
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Oct 31, 2014
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Abstract
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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