Chemical compounds
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United States of America Patent
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Dec 19, 2017
Grant Date -
Dec 29, 2016
app pub date -
Jun 27, 2016
filing date -
Jun 29, 2015
priority date (Note) -
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Abstract
Provided are a series of novel pyridine or pyrimidine derivatives which inhibit CDK9 and may be useful for the treatment of hyperproliferative diseases. In particular the compounds are of use in the treatment of proliferative disease such as cancer including hematological malignancies such as acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, diffuse large B cell lymphoma, Burkitt's lymphoma, follicular lymphoma and solid tumors such as breast cancer, lung cancer, neuroblastoma and colon cancer.
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