Method for preparing in situ-formed hydrogel using enzyme-immobilized support, and biomedical use thereof

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United States of America Patent

PATENT NO 9844610
APP PUB NO 20150250890A1
SERIAL NO

14429576

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Abstract

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The present invention relates to a method for preparing a hydrogel, including the steps of: preparing an enzyme-immobilized support; making contacting with a polymer having a phenol or aniline functional group at a side change and the support in the presence of hydrogen peroxide to cross-link the same; and obtaining a hydrogel by separating the enzyme-immobilized support. According to the present invention, a hydrogel is formed by cross-linking a polymer having a phenol or aniline functional group at a side chain through an enzyme-immobilized support, and thus a hydrogel containing no enzymes is obtained. Therefore, the biomedical application range of a hydrogel can be expanded since it is possible to overcome an in vivo safety problem such as immune reaction caused by an enzyme.

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Patent Owner(s)

Patent OwnerAddress
AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION206 WORLD CUP-RO SUWON-SI YEONGTONG-GU GYEONGGI-DO 16499 16499

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bae, Jin Woo Suwon-si, KR 26 183
Kim, Bae Young Gwangju, KR 2 1
Lee, Yunki Seongnam-si, KR 26 29
Lih, Eugene Seoul, KR 3 1
Park, Ki Dong Seoul, KR 17 204
Park, Kyung Min Anyang-si, KR 78 460

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