Bacterial RNAs as vaccine adjuvants

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United States of America Patent

PATENT NO 9844592
SERIAL NO

14233631

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Abstract

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The disclosure features vaccine adjuvants comprising prokaryotic mRNA, and methods of vaccination using the adjuvants. More specifically, the disclosure provides a vaccine composition comprising a nonviable immunogen (e.g., heat-killed bacterium), a tumor antigen, or an immunogenic peptide of microbial or mammalian origin, and an adjuvant, wherein adjuvant comprises prokaryotic mRNA (e.g., bacterial mRNA), as well as the methods of using the vaccine compositions. Further disclosed are the structural features of the prokaryotic mRNA used as the adjuvants.

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Patent Owner(s)

Patent OwnerAddress
CORNELL UNIVERSITYCCTEC - 395 PINE TREE ROAD SUITE 310 ITHACA NY 14850

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blander, Julie Magarian North Haven, US 7 15
Sander, Leif Erik Berlin, DE 3 5

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