Methods for evaluating viral receptor/co-receptor usage and inhibitors of virus entry using recombinant virus assays
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United States of America Patent
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Dec 12, 2017
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app pub date -
Oct 29, 2015
filing date -
Feb 15, 2002
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Abstract
Provided are methods for identifying whether a compound inhibits entry of a virus into a cell. The method may include obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus and co-transfecting it into a first cell along with a viral expression vector which lacks a nucleic acid encoding the envelope protein. The method may further include contacting the viral particles produced by the first cell with a second cell to which the virus binds in the absence and presence of the compound and measuring the amount of signal produced by the second cell.
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