Compositions and methods for altering second messenger signaling
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United States of America Patent
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Dec 12, 2017
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app pub date -
Apr 29, 2014
filing date -
Apr 29, 2013
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Abstract
The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.
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International Classification(s)
- C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C12Q:MEASURING OR TESTING PROCESSES INVOLVING ENZYMES O....
- C07F:ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CO....
- G06F:ELECTRIC DIGITAL DATA PROCESSING
- G06K:RECOGNITION OF DATA; PRESENTATION OF DATA; RECORD ....
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