Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
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United States of America Patent
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Dec 12, 2017
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app pub date -
Oct 10, 2014
filing date -
Oct 11, 2013
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Abstract
Provided herein are modified amino acids comprising a tetrazine groups according to Formula I: polypeptides, antibodies, payloads and conjugates comprising these modified amino acid residues derived from the modified amino acids, and methods of producing the polypeptides, antibodies, payloads and conjugates comprising the modified amino acid residues. The polypeptides, antibodies, payloads and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.
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