Compartmentalised combinatorial chemistry by microfluidic control
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United States of America Patent
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Dec 12, 2017
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app pub date -
Oct 12, 2005
filing date -
Mar 31, 2004
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Abstract
The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control, The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.
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International Classification(s)
- B82Y:SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; ....
- B01L:CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENE....
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- B01J:CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, CO....
- C40B:COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL ....
- B01F:MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
- C07K:PEPTIDES
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