Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins
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United States of America Patent
Stats
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Dec 12, 2017
Issued Date -
N/A
app pub date -
Apr 27, 2015
filing date -
Aug 30, 2005
priority date (Note) -
In Force
status (Latency Note)
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Abstract
This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. TNFR25 agonists disclosed herein have an anti-inflammatory and healing effect. They can be used, e.g., to treat disease caused by asthma and chronic inflammation, such as inflammatory bowel diseases including ulcerative colitis and Crohn's Disease. TNFR25 antagonists disclosed herein can inhibit CD8 T cell-mediated cellular immune responses and can, for example, mitigate organ or tissue rejection following a tissue transplantation. TNFR25 agonists disclosed herein represent biological response modifiers that alter the interaction between the body's cellular immune defenses and cancer cells to boost, direct, or restore the body's ability to fight the cancer when given with tumor vaccines. TNFR25 specific immunotoxins disclosed herein are also capable of increasing the effectiveness of a chemotherapeutic regimen by depleting a cancer patient of naturally occurring immunosuppressive cells.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
UNIVERSITY OF MIAMI | 1951 NW 7TH AVENUE MIAMI FL 33136 |
International Classification(s)

- 2015 Application Filing Year
- A61K Class
- 16157 Applications Filed
- 11882 Patents Issued To-Date
- 73.55 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Deyev, Vadim | Miami, US | 8 | 109 |
# of filed Patents : 8 Total Citations : 109 | |||
Levy, Robert | Cooper City, US | 46 | 1320 |
# of filed Patents : 46 Total Citations : 1320 | |||
Podack, Eckhard R | Coconut Grove, US | 30 | 325 |
# of filed Patents : 30 Total Citations : 325 |
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Patent Citation Ranking
- 12 Citation Count
- A61K Class
- 93.51 % this patent is cited more than
- 8 Age
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Feb 27, 2015 | PD | Priority Date |

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