Methods and means for metabolic engineering and improved product formation by micro-organisms

United States of America Patent

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Dec 5, 2017
Grant Date
Jun 16, 2011
app pub date
Feb 14, 2007
filing date
Feb 14, 2006

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Abstract

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Described are methods and means for metabolic engineering and improved product formation by a filamentous micro-organism or a low G+C gram-positive bacterium. Disclosed is that DasR and DasR binding sites play an important and universal role in the control of gene expression in micro-organisms. Based on this finding, provided are multiple useful applications, such as a method for regulating the expression of a gene of interest, a method for controlling metabolism, a method for decreasing undesired expression and many more. Moreover, provided are means that can be used to establish said methods: for example a micro-organism in which the DasR binding site in operable linkage with a particular gene has been modified to obtain increased or decreased expression of a protein (being a desired or undesired protein) encoded by said gene.

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Country	kind	publication No.	Filing Date	Type	Sub-Type
EP	A1	EP1818398	Feb 14, 2006	Patent	Application
Type : Patent Sub-Type : Application
APPLICATION PUBLISHED WITH SEARCH REPORT		Methods and means for metabolic engineering and improved product formation by micro-organisms		Aug 15, 2007
EP	A1	EP1991674	Feb 14, 2007	Patent	Application
Type : Patent Sub-Type : Application
APPLICATION PUBLISHED WITH SEARCH REPORT		METHODS AND MEANS FOR METABOLIC ENGINEERING AND IMPROVED PRODUCT FORMATION BY MICRO-ORGANISMS		Nov 19, 2008
CA	A1	CA2642528	Feb 14, 2007	Patent	Application
Type : Patent Sub-Type : Application
APPLICATION LAID OPEN		METHODS AND MEANS FOR METABOLIC ENGINEERING AND IMPROVED PRODUCT FORMATION BY MICRO-ORGANISMS		Aug 23, 2007
JP	A	JP2009526548	Feb 14, 2007	Patent	Application
Type : Patent Sub-Type : Application
Published unexamined patent application		METHODS AND MEANS FOR METABOLIC ENGINEERING AND IMPROVED PRODUCT FORMATION BY MICRO-ORGANISMS		Jul 23, 2009
WO	A1	WO2007094667	Feb 14, 2007	Patent	Application
Type : Patent Sub-Type : Application
INTERNATIONAL APPLICATION PUBLISHED WITH INTERNATIONAL SEARCH REPORT		METHODS AND MEANS FOR METABOLIC ENGINEERING AND IMPROVED PRODUCT FORMATION BY MICRO-ORGANISMS		Aug 23, 2007

Patent Owner(s)

Patent Owner	Address
UNIVERSITEIT LEIDEN	2311 EZ LEIDEN
FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NURNBERG	91054 ERLANGEN
UNIVERISTY OF LIEGE	QUAI VAN BENEDEN 25 LIEGE 4020

International Classification(s)

2007 Application Filing Year
C12N Class
4103 Applications Filed
1800 Patents Issued To-Date
43.88 % Issued To-Date

Inventor(s)

Inventor Name	Address	# of filed Patents	Total Citations
Rigali, Sebastien	Angleur, BE	3	2
# of filed Patents : 3 Total Citations : 2
Titgemeyer, Mannfred Friedrich Bruno	Möhrendorf, DE	1	0
# of filed Patents : 1 Total Citations : 0
Van, Wezel Gilles Philippus	Oegstgeest, NL	10	9
# of filed Patents : 10 Total Citations : 9

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Methods and means for metabolic engineering and improved product formation by micro-organisms

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United States of America Patent

12224050

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PATENT NO	9834773
APP PUB NO	20110143394A1
SERIAL NO	12224050
DOCKET NO

Fee	Large entity fee	small entity fee	micro entity fee
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Surcharge - 11.5 year - Late payment within 6 months	$160.00	$80.00	$40.00
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DATE PUBLISHED	PUBLICATION/PATENT NO.	PUBLICATION TYPE
December 05, 2017	US,9834773,B2 US9834773B2	GRANTED PATENT AS SECOND PUBLICATION
June 16, 2011	US,20110143394,A1 US20110143394A1	FIRST PUBLISHED PATENT APPLICATION

Date	Code	Event	Description
May 27, 2021	MAFP	MAINTENANCE FEE PAYMENT	free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY year of fee payment: 4
Dec 05, 2017	I	Issuance
Nov 15, 2017	STCF	INFORMATION ON STATUS: PATENT GRANT	free format text: PATENTED CASE
Jun 16, 2011	P	Published
Jun 01, 2011	AS	ASSIGNMENT	free format text: CHANGE OF ADDRESS OF ONE OF THE ASSIGNEES(AND CORRECTION OF THE SPELLING OF UNIVERSITY)-CORRECTION OF DOCUMENTS PREVIOUSLY SUBMITTED WITH DOCUMENT ID NO:103626583;ASSIGNOR:UNIVERSITY OF LIEGE;REEL/FRAME:026567/0317 Owner name: UNIVERSITY OF LIEGE, BELGIUM Effective Date: Jun 01, 2011
Jul 12, 2010	AS	ASSIGNMENT	free format text: CORRECTIVE ASSIGNMENT TO CORRECT ADDRESS OF THE SECOND ASSIGNEE'S STREET ADDRESS. QUAI VAN BENEDEN, 25; POSTAL CODE SHOULD BE: 4020;ASSIGNORS:RIGALI, SEBASTIEN;TITGEMEYER, MANNFRED F. B.;VAN WEZEL, GILLES P.;SIGNING DATES FROM 20090225 TO 20090310;REEL/FRAME:024675/0498 Owner name: UNIVERSITEIT LEIDEN, NETHERLANDS free format text: CORRECTIVE ASSIGNMENT TO CORRECT ADDRESS OF THE SECOND ASSIGNEE'S STREET ADDRESS. QUAI VAN BENEDEN, 25; POSTAL CODE SHOULD BE: 4020;ASSIGNORS:RIGALI, SEBASTIEN;TITGEMEYER, MANNFRED F. B.;VAN WEZEL, GILLES P.;SIGNING DATES FROM 20090225 TO 20090310;REEL/FRAME:024675/0498 Owner name: UNIVERISTY OF LIEGE, BELGIUM free format text: CORRECTIVE ASSIGNMENT TO CORRECT ADDRESS OF THE SECOND ASSIGNEE'S STREET ADDRESS. QUAI VAN BENEDEN, 25; POSTAL CODE SHOULD BE: 4020;ASSIGNORS:RIGALI, SEBASTIEN;TITGEMEYER, MANNFRED F. B.;VAN WEZEL, GILLES P.;SIGNING DATES FROM 20090225 TO 20090310;REEL/FRAME:024675/0498 Owner name: FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NURNBERG,
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