IgG stimulated remyelination of peripheral nerves

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United States of America Patent

PATENT NO 9834593
APP PUB NO 20150232536A1
SERIAL NO

14625542

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Abstract

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The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

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Patent Owner(s)

Patent OwnerAddress
TAKEDA PHARMACEUTICAL COMPANY LIMITED1-1 DOSHOMACHI 4-CHOME CHUO-KU OSAKA-SHI OSAKA 541-0045 JAPAN

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bunk, Sebastian Vienna, AT 70 156
Ehrlich, Hartmut Vienna, AT 46 206
Hartung, Hans-Peter Düsseldorf, DE 7 2
Hermann, Corinna Vienna, AT 5 0
Küry, Patrick Düsseldorf, DE 8 3
Reipert, Birgit Maria Deutsch-Wagram, AT 11 19
Schwarz, Hans-Peter Vienna, AT 143 1170
Tzekova, Nevena Düsseldorf, DE 5 0

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