Enhanced sensitivity for analysis of ketosteroid compounds using mass spectrometry
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United States of America Patent
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Dec 5, 2017
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May 24, 2011
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May 27, 2010
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Abstract
The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for detection of a carbonyl group-containing compound by mass spectrometry can comprise derivatizing the carbonyl group-containing compound with an O-substituted hydroxylamine thereby producing an oxime, resulting in enhanced sensitivity of detection by mass spectrometry, as compared to the underivatized carbonyl group-containing compound.
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