Pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (KDMs)
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United States of America Patent
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Dec 5, 2017
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Oct 27, 2015
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Oct 29, 2014
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Abstract
The present invention provides a compound of Formula (I) being capable of modulating the activity of histone lysine demethylase (KDM), pharmaceutical compositions thereof, methods to prepare the said compounds, and the use of such compounds as a medicament. The compound of Formula (I) acts as KDM inhibitor with marked potency, thereby having an outstanding potential for a pharmaceutical intervention of cancer and any other diseases related to KDM dysregulation.
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