3-furyl-2-cyano-2-acrylamide derivative, preparation method therefor, pharmaceutical composition and use thereof

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United States of America Patent

PATENT NO 9834530
SERIAL NO

15170871

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Abstract

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Disclosed are a 3-furyl-2-cyano-2-acrylamide derivative with epidermal growth factor receptor (EGFR) inhibitory activity and pharmaceutical acceptable salt thereof, together with preparation method thereof, pharmaceutical composition comprising the compound, and application of the compound in treating senile dementia (AD). The new compound is shown as formula I, wherein R1 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl and C3-C6 cycloalkyl; R2 is selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl and heteroaralkyl; X is selected from the group consisting of CH2, NH, O and S; m and n are all integers greater than or equal to zero.

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Patent Owner(s)

Patent OwnerAddress
JENKEM TECHNOLOGY CO LTD (BEIJING)3/F BUILDING C-1 ZHONGGUANCUN DONGSHENG SCIENCE AND TECHNOLOGY PARK 66 XIXIAOKOU ROAD HAIDIAN DISTRICT BEIJING 100192 100192

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Feng, Zewang Beijing, CN 27 65
Jia, Jianhuan Beijing, CN 3 26
Liu, Yan Beijing, CN 664 5733
Wang, Zhenguo Beijing, CN 64 238
Zhao, Xuan Beijing, CN 202 3301

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