Liquid formulation of long-acting insulin and insulinotropic peptide

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United States of America Patent

PATENT NO 9833516
SERIAL NO

14416231

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Abstract

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The present invention relates to a liquid formulation of a combination of long-acting insulin and insulinotropic peptide, comprising insulin which is a physiologically active peptide, insulinotropic peptide, and albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent; and a method for preparing the liquid formulation. The liquid formulation of the present invention does not contain a human serum albumin and potentially toxic factors to the body, and thus it has excellent storage stability for insulin conjugate and insulinotropic peptide conjugate at high concentration, without a risk of viral contamination.

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Patent Owner(s)

  • HANMI PHARM. CO., LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bae, Sung Min Seongnam-si, KR 50 410
Kim, Hyun Uk Busan, KR 36 160
Kwon, Se Chang Seoul, KR 120 1146
Lee, Jong Soo Seongnam-si, KR 85 376
Lee, Mi Kyoung Seoul, KR 17 105
Lim, Hyung Kyu Hwaseong-si, KR 22 62

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