Methods for producing polypeptides by regulating polypeptide association
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United States of America Patent
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Nov 28, 2017
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Jan 21, 2010
app pub date -
Mar 31, 2006
filing date -
Mar 31, 2005
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Abstract
In the course of the present invention, it was discovered that one could regulate association between polypeptides by modifying amino acid residues that form the interface during the association to amino acids carrying the same type of charge. In this context, the present invention enables efficient formation of heterologous molecules. For example, the present invention can be suitably applied to the preparation of bispecific antibodies.
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