Fractionation of charged polysaccharide

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United States of America Patent

PATENT NO 9828443
APP PUB NO 20160159935A1
SERIAL NO

14924634

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Abstract

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Polydisperse and charged polysaccharides are fractionated into low polydispersity fractions (preferably having pd<1.1), each containing species within a narrow range of molecular weights. An aqueous solution of the polydisperse polysaccharides is contacted with an ion exchange resin in a column and the polysaccharides are subjected to selective elution by aqueous elution buffer. The selective elution consists of at least 3 sequential elution buffers having different and constant ionic strength and/or pH and in which the subsequent buffers have ionic strength and/or pH than those of the preceding step. The new preparations are particularly suitable for the production of PSA-derivatized therapeutic agents intended for use in humans and animals.

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Patent Owner(s)

Patent OwnerAddress
LIPOXEN TECHNOLOGIES LIMITEDLONDON BIOSCIENCE INNOVATION CENTER 2 ROYAL COLLEGE STREET LONDON NW1 0NH

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jain, Sanjay London, GB 115 1620
Laing, Peter London, GB 67 450
Papaioannou, Ioannis London, GB 24 79

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