Asymmetric synthesis of a substituted pyrrolidine-2-carboxamide

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United States of America Patent

PATENT NO 9828340
SERIAL NO

14766049

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Abstract

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The invention relates to a process for the preparation of 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid of the formula (I)

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Patent Owner(s)

Patent OwnerAddress
HOFFMANN-LA ROCHE INC150 CLOVE ROAD OVERLOOK AT GREAT NOTCH SUITE 8 LITTLE FALLS NJ 07424

International Classification(s)

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  • 2014 Application Filing Year
  • C07D Class
  • 5203 Applications Filed
  • 4627 Patents Issued To-Date
  • 88.93 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fishlock, Daniel Basel, CH 4 77
Gu, Chen Lake Hiawatha, US 14 34
Rege, Pankaj Devdatta Basel, CH 1 0
Sarma, Keshab Sunnyvale, US 28 765
Shu, Lianhe Livingston, US 10 25

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  • C07D Class
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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges158718941835528419501 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7081 - 90010020030040050060070080090010001100120013001400150016001700180019002000

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