Drug delivery of temozolomide for systemic based treatment of cancer

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United States of America Patent

PATENT NO 9827325
SERIAL NO

15450519

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Abstract

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The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety. The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety.

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Patent Owner(s)

Patent OwnerAddress
CEDARS-SINAI MEDICAL CENTER8700 BEVERLY BOULEVARD LOS ANGELES CA 90048

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Black, Keith L Los Angeles, US 61 611
Holler, Eggehard Los Angeles, US 18 64
Ljubimova, Julia Y Studio City, US 19 87
Patil, Rameshwar Los Angeles, US 5 18

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