Live attenuated vaccines for influenza viruses
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United States of America Patent
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Nov 28, 2017
Grant Date -
May 19, 2016
app pub date -
Nov 13, 2015
filing date -
Nov 13, 2014
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Abstract
The subject invention pertains to attenuated influenza viruses, and related vaccines and methods, comprising a genetically modified viral genome. The genetically modified viral genome comprises a disruption in the non-structural (NS1) coding segment and one or more base substitution in the matrix membrane protein coding segment. The genetic modifications result in viruses that lose NS1 functionality, yet remain replication competent.
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