Selectively disrupted whole-cell vaccine

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United States of America Patent

PATENT NO 9827299
APP PUB NO 20120251577A1
SERIAL NO

13500925

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Abstract

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The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.

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Patent Owner(s)

Patent OwnerAddress
FUNDACAO BUTANTANAV VITAL BRASIL 1500 SAO PAULO 05503-900

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alderson, Mark Bainbridge Island, US 27 367
Anderson, Porter Key Largo, US 2 14
de, Oliveira Dias Waldely Sao Paulo, BR 1 6
Lu, Yingjie West Roxbury, US 32 171
Maimoni, Gonçalves Viviane Sao Paulo, BR 1 6
Maisonneuve, Jean-Francois Lucien Federal Way, US 5 21
Malley, Richard Beverly, US 40 216
Robertson, George A Fairfax Station, US 1 6
Tate, Andrea Maria Issaquah, US 1 6

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