Neurotoxins exhibiting shortened biological activity
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United States of America Patent
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Nov 28, 2017
Grant Date -
Mar 16, 2017
app pub date -
Nov 3, 2016
filing date -
Jul 2, 2009
priority date (Note) -
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Abstract
The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a Neurotoxin polypeptide exhibiting a reduced duration of biological effect in a subject, wherein the polypeptide comprises at feast one degradation signal in the light chain as well as vectors and host calls comprising the polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising the polynucleotides and polypeptides as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments.
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