Compositions and methods relating to induction of intestinal stem cell homeogenesis and/or regeneration
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Nov 28, 2017
Issued Date -
N/A
app pub date -
Feb 25, 2014
filing date -
Feb 28, 2013
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The present invention relates to compositions and methods for inducing intestinal stem cell homeogenesis and/or regeneration within intestinal tissue expressing Robo1 through administration of a Rspo1 agent and a Slit2 agent. Administration of such agents results in, for example, binding of the Rspo1 agent and Slit2 agent with Robo1, resulting in, for example, binding of the CC3 motif of Robo1 with LRP6, resulting in phosphorylation of LRP6, and ultimately, induction of intestinal stem cell homeogenesis and/or regeneration. In certain embodiments, such administration of a Rspo1 agent and a Slit2 agent is used to protect and/or prevent intestinal tissue damage resulting from exposure to an intestinal tissue damaging event (e.g., radiation). The agents and related compositions additionally find use in diagnostic and research settings.
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully