In vitro method for predicting in vivo genotoxicity of chemical compounds
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United States of America Patent
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Nov 21, 2017
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Jul 10, 2014
app pub date -
May 19, 2012
filing date -
May 19, 2011
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Abstract
The invention is in the field of genomics and it provides an in vitro method for predicting whether a compound is genotoxic in vivo. In particular, the invention provides a method for predicting the in vivo genotoxicity of a compound comprising the steps of performing an Ames test on the compound and determining if the result is positive or negative, followed by a step wherein the gene expression of at least 3 genes is determined in a HepG2 cell, compared to a reference value and predicting that the compound is in vivo genotoxic if the expression level of more than 2 of the genes is above a reference value.
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