Nucleic acid for treatment or prevention of immunodeficiency virus infection
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United States of America Patent
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Nov 21, 2017
Grant Date -
Feb 5, 2015
app pub date -
Oct 16, 2014
filing date -
Aug 16, 2005
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Abstract
A nucleic acid comprising a transcription regulation sequence whose transcription is induced by a trans-acting factor of a human immunodeficiency virus and a gene encoding a polypeptide having an endoribonuclease activity specific to single-stranded RNA, wherein the gene is located in such a position that the expression of the gene can be regulated by the transcription regulation sequence; a method for production of a cell showing an inhibited replication of a human immunodeficiency virus therein, the method comprising the step of introducing the nucleic acid into a cell; and a method for treatment or prevention of a human immunodeficiency virus infection.
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