Amyloid beta expression constructs and uses therefor
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United States of America Patent
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Nov 21, 2017
Grant Date -
Dec 17, 2015
app pub date -
Jun 12, 2015
filing date -
Jun 13, 2014
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Abstract
Disclosed are yeast expression constructs encoding a polypeptide containing a signal sequence, a Golgi-directing pro sequence, and a human amyloid beta protein, and mammalian expression constructs encoding a polypeptide containing a selected signal sequence and a human amyloid beta protein. Also disclosed are methods of screening cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.
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