Aminoglycosides and uses thereof in the treatment of genetic disorders

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9821001
APP PUB NO 20150352136A1
SERIAL NO

14738892

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Abstract

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A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

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Patent Owner(s)

Patent OwnerAddress
BAXTER INTERNATIONAL INCONE BAXTER PARKWAY DEERFIELD IL 60015
BAXTER HEALTHCARE SATHURGAUERSTRASSE 130 GLATTPARK (OPFIKON) CH-8152

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baasov, Timor Haifa, IL 30 157
Ben-Yosef, Tamar Haifa, IL 4 16
Hainrichson, Mariana Kiryat-Yam, IL 6 19
Nudelman, Igor Haifa, IL 11 44
Rebibo-Sabbah, Annie Haifa, IL 4 16
Shallom-Shezifi, Dalia Kibbutz Nasholim, IL 4 16

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