Use of bisphosphonates as HIV/AIDS adjunctive treatment
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United States of America Patent
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Nov 21, 2017
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app pub date -
May 15, 2015
filing date -
May 16, 2014
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Abstract
The present invention relates to use of bisphosphonate formulations for the treatment and management of HIV/AIDS. The method of the invention comprises administering a formulation comprising an effective amount of a bisphosphonate that specifically inhibits the activity and/or decreases the number of monocytes and/or macrophages, thereby reducing or eliminating HIV reservoirs. The invention also provides a method of complementing an HIV antiviral therapy, such as the highly active antiretroviral therapy (HAART), with a bisphosphonate formulation to improve clinical outcome.
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