Bioprobes and methods of use thereof

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United States of America Patent

PATENT NO 9816129
SERIAL NO

15091369

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Abstract

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Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bin-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.

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Patent Owner(s)

Patent OwnerAddress
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOTORONTO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fang, Zhichao Toronto, CA 8 92
Kelley, Shana O Toronto, CA 27 500
Vasilyeva, Elizaveta Toronto, CA 3 15

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