TrkA kinase inhibitors, compositions and methods thereof

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United States of America Patent

PATENT NO 9815846
SERIAL NO

15128689

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Abstract

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The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Babaoglu, Kerim Lansdale, US 26 319
Bao, Jianming Shanghai, CN 57 276
Chen, Yi-Heng Whippany, US 23 176
Cooke, Andrew J West Point, US 7 7
Fraley, Mark E North Wales, US 90 1087
Li, Chun Sing Shanghai, CN 43 246
Liu, Ping Westfield, US 587 9247
Mao, Qinghua Shanghai, CN 13 7
McComas, Casey C Phoenixville, US 15 18
McWherter, Melody Boyertown, US 9 14
Meng, Dongfang Morganville, US 31 198
Mercer, Swati P Philadelphia, US 17 205
Mitchell, Helen Richboro, US 7 15
Qi, Zhiqi Shanghai, CN 12 19
Schirripa, Kathy Quakertown, US 5 7
Stump, Craig A West Point, US 51 304
Wood, Harold B Westfield, US 33 69
Wu, Jane Marlboro, US 3 11
Zhang, Xu-Fang Dresher, US 11 71

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