Method for concentrating cells that are genetically altered by nucleases
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United States of America Patent
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Nov 7, 2017
Issued Date -
Feb 13, 2014
app pub date -
Feb 22, 2012
filing date -
Feb 22, 2011
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Abstract
The present invention relates to a reporter construct and method for identifying or enriching the cells, wherein a specific endogenous nucleotide sequence is cleaved by a specific nuclease or modified by such cleavage; a host cell comprising the reporter construct; and a system for monitoring a nuclease activity. The reporter system of the present invention is simple and non-invasive, and allows for an efficient enrichment of the gene-modified cells. Therefore, the present invention will promote the application of a nuclease in the field of gene therapy and genetic engineering as well as basic research.
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