Method of synthesizing 25-hydroxy cholesterol

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United States of America Patent

PATENT NO 9802977
SERIAL NO

15329255

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The present invention discloses a method for synthesizing 25-hydroxy cholesterol. The method is as below: subjecting 24-dehydrocholesterol derivative as a raw material, which undergoes an addition reaction with a hydroxyl containing reagent in an organic solvent under catalysis, and then hydrolyzing the reaction product and separating to obtain 25-hydroxy cholesterol. The present invention adopts hydroxyl containing reagents such as water, formic acid, acetic acid, propionic acid, butyric acid, benzoic acid, p-methyl benzoic acid to replace the commonly used extremely toxic reagents such as Cr reagent, Hg reagent and polyfluorinated acetone in the prior art. The raw materials of the present invention are easily available, and have low effect on environment. The operation and post treatment are convenient. Moreover, the method has the advantages of mild reaction conditions, simple operation, good selectivity, high efficiency, high yield, simple post treatment, easy product separation, less three wastes and easy industrialization.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG UNIVERSITY OF TECHNOLOGY310014 ZHEJIANG UNIVERSITY OF TECHNOLOGY 18 CHAOWANG ROAD HANGZHOU ZHEJIANG HANGZHOU CITY ZHEJIANG PROVINCE 310014
ZHEJIANG GARDEN BIOCHEMICAL HIGH-TECH CO LTDGARDEN INDUSTRIAL ZONE DONGYANG ZHEJIANG 322121
HANGZHOU XIASHA BIOCHEMICAL TECH CO LTDNO 166 20 AVENUE XIASHA ECONOMIC DEVELOPMENT ZONE HANGZHOU ZHEJIANG 310018

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jin, Can Zhejiang, CN 20 131
Liu, Jiangang Zhejiang, CN 9 133
Su, Weike Zhejiang, CN 1 0
Sun, Bin Zhejiang, CN 110 267
Wang, Ziqiang Zhejiang, CN 33 166
Xu, Wenhao Zhejiang, CN 6 1

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