Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
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United States of America Patent
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Oct 31, 2017
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app pub date -
Oct 3, 2016
filing date -
Aug 27, 2007
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Abstract
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
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