Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
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United States of America Patent
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Oct 31, 2017
Grant Date -
Apr 30, 2009
app pub date -
Oct 9, 2007
filing date -
Jul 5, 2002
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Abstract
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of ketones.
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