Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof

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United States of America Patent

PATENT NO 9802904
SERIAL NO

14655538

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Abstract

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Disclosed are inhibitors of the USP1/UAF1 deubiquitinase complex, for example. of formula (I), wherein R1, R2, and Q are as defined herein, which are useful in treating diseases such as cancer, and improving the efficacy of DNA damaging agents in cancer treatment. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a heterodimeric deubiquitinase complex in a cell, and a method of enhancing the chemotherapeutic treatment of cancer in a mammal undergoing treatment with an anti cancer agent. Further disclosed is a method of preparing compounds of the invention.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESOFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE SUITE 700 MSC 7788 BETHESDA MD 20892-7788
UNIVERSITY OF DELAWAREOFFICE OF ECONOMIC INNOVATION AND PARTNERSHIPS 591 COLLABORATION WAY SECOND FLOOR NEWARK DE 19713

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dexheimer, Thomas S Frederick, US 4 10
Jadhav, Ajit Chantilly, US 22 68
Liang, Qin Elkton, US 9 5
Luci, Diane K Germantown, US 12 28
Maloney, David J Point of Rocks, US 34 503
Rosenthal, Andrew S Derwood, US 2 3
Simeonov, Anton Bethesda, US 33 141
Zhuang, Zhihao Wilmington, US 2 3

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