Quinoline derivatives as PDE10A enzyme inhibitors
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United States of America Patent
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Oct 31, 2017
Grant Date -
Oct 20, 2016
app pub date -
Nov 13, 2015
filing date -
Dec 21, 2011
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Abstract
The present invention provides quinoline derivatives of formula I that are PDE10A enzyme inhibitors, and as such are useful to treat neurodegenerative and psychiatric disorders. Especially, the invention provides compounds that are highly selective for PDE10A over other PDE subtypes. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.
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