Unnatural reactive amino acid genetic code additions
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United States of America Patent
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Oct 24, 2017
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Jul 22, 2014
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Jun 18, 2003
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Abstract
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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