Method and system for determining a biological response of a target to a soluble candidate substance
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United States of America Patent
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Oct 24, 2017
Grant Date -
Jan 14, 2016
app pub date -
Mar 4, 2014
filing date -
Mar 5, 2013
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Abstract
A method for determining a biological response of a target (41, 42) to a soluble candidate substance includes the steps:
- introducing a soluble candidate substance into a laminar flow of a buffer liquid (2) to form a candidate substance solute (3) having an initial concentration profile (31);dispersing the initial concentration profile (31) to form a dispersed concentration profile (32);directing the dispersed concentration profile (32) into a detection channel (12) to form a final symmetrical concentration profile (33) therein;introducing a target into the detection channel (12) to obtain a combined concentration profile including a constant target concentration profile overlying the final symmetrical concentration profile (33);holding in the detection channel (12) at least one half of the combined concentration profile; andoptically scanning the combined concentration profile to detect an optical signal representative of the biological response of the target to the soluble candidate substance.
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