Ketoreductase polypeptides

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United States of America Patent

PATENT NO 9796964
SERIAL NO

15211505

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Abstract

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The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl (1,3-oxazolidin-3-yl))-1-(4-fluorophenyl) pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe.

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Patent Owner(s)

Patent OwnerAddress
CODEXIS INCREDWOOD CITY CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Vries Erik Jan Livermore, US 8 15
Mundorff, Emily Garden City, US 99 1254

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