Binding proteins specific for insulin-like growth factors and uses thereof
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United States of America Patent
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Oct 24, 2017
Grant Date -
Mar 31, 2016
app pub date -
Oct 6, 2015
filing date -
Dec 13, 2005
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Abstract
Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the IGF-II with cross-reactivity to IGF-I are disclosed. Also discussed are nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3.
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