Glucocerebrosidase modulators and uses thereof
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United States of America Patent
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Oct 24, 2017
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Dec 22, 2014
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Dec 23, 2013
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Abstract
The invention provides isofogamine analogs of structural formula (I) below that modulate and stabilize glucocerebrosidases and enhance their enzymatic activity in vivo. Such compounds, prodrugs and compositions thereof are useful in treating synucleinopathy, lysosomal storage disease and relevant neurodegenerative disease.
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