Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal

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United States of America Patent

PATENT NO 9795715
SERIAL NO

14218039

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Abstract

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Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.

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Patent Owner(s)

  • ZIMMER TRABECULAR METAL TECHNOLOGY, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bunger, Cody Auning, DK 5 51
Li, Haisheng Viby J., DK 8 51
Xuenong, Zou Aarhus N., DK 5 51

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