Method for measuring ATR inhibition mediated increases in DNA damage

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United States of America Patent

PATENT NO 9791456
SERIAL NO

14633394

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Abstract

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The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of γH2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.

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Patent Owner(s)

Patent OwnerAddress
VERTEX PHARMACEUTICALS (EUROPE) LIMITED86-88 JUBILEE AVENUE MILTON PARK ABINGDON OXFORDSHIRE OX14 4RW

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Tao SuZhou, CN 1087 14323
Curtin, Nicola Newcastle upon Tyne, GB 4 117
Falcon, Susanna Newbury, GB 2 79
Middleton, Fiona South Gosforth, GB 2 79
Pollard, John Abingdon, GB 18 171
Reaper, Philip Shillingford, GB 2 79

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