Compositions and methods for the detection or treatment of uterine leiomyosarcoma
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United States of America Patent
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Oct 17, 2017
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app pub date -
Sep 30, 2016
filing date -
Sep 30, 2015
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Abstract
Compositions and methods for the detection and treatment of cancer are provided. It has been discovered that uterine cancer cells selectively induce the survivin promoter to express a gene product. One embodiment provides a method for detecting uterine malignancy by systemic administration of a cancer-specific vector that utilizes a Survivin promoter to drive expression of a reporter gene. The expression of the reporter gene is detectable exclusively in malignant cells, for example using conventional imagining techniques.
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